Animal study · Exercise · 28 Oct 2026
A liver-targeted splicing factor extended median lifespan in female mice
Source: Lifespan.io
What the research found
Lifespan.io reported on 28 October 2026 a Nature Aging paper by Alex M. Plesa, George M. Church, and colleagues. A gene-expression screen in human skin fibroblasts, trained on donors aged 1 to 96, ranked the splicing factor SRSF1 as a strong hit for a more youthful transcriptomic pattern without the full loss of cell identity seen with Yamanaka factors. In aged mice, a liver-targeted viral vector cut a frailty score by 44 percent, sped wound closure, and extended median lifespan by 14 percent. That mouse experiment used 9 to 10 female mice per group. A higher, always-on dose did not improve wound repair or muscle regeneration. This is not a gene therapy people can obtain. Not medical advice.
Evidence level: Animal study. Results in animals or cells often don't carry over to people.
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