Clinical trial · Exercise · 1 Nov 2026
Resistance exercise plus essential amino acid intake beat either one alone for muscle fitness in women over 65
Source: PubMed
What the research found
Jeong and colleagues randomized 96 healthy women over 65 (aged at least 65) to 12 weeks of control, resistance exercise, essential amino acid intake, or both (PMID 41863133; DOI 10.1080/15502783.2026.2646626; JISSN). The issue date is 31 December 2026 and the paper was online on 21 March 2026. The card date is 1 November 2026 so a future issue date is not stored and the March date does not drop out of the newest list. The circuit was three times a week, 60 minutes, moderate. Amino acids were 5.5 grams twice a day. The combination did better than either approach alone for muscle mass (partial eta-squared 0.174, p < 0.001) and for the follistatin to myostatin ratio (partial eta-squared 0.188, p = 0.002). Myostatin fell, follistatin rose in the resistance group and in the combination, and inflammatory markers moved down: IL-6 and IL-1beta in the resistance group and the combination, TNF-alpha only in the combination. There is a control group. This is one trial. It does not prove the combination prevents sarcopenia. Not medical advice.
Evidence level: Clinical trial. This is among the stronger kinds of evidence, but one study rarely settles a question.
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