
EurekAlert · 22 Sept 2026 · Nutrition
Excess free cysteine pried iron from ferritin and killed cells via mitochondria in a Rockefeller study
Study (cell). Toshitaka Nakamura, Kivanç Birsoy and Rockefeller colleagues report in Nature Metabolism that excess cysteine mobilizes iron from ferritin, floods mitochondria via SLC25A28, and triggers iron-dependent cell death. Glutathione does not do this, which may explain why cells spend energy packing cysteine into glutathione. Cell biology, not a diet trial. Educational research notes, not an amino-acid warning label.
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