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Newest story: 10 Nov 2026

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GeroScience · 9 Nov 2026 · Aging

In 37 people on the Alzheimer spectrum and 43 cognitively normal adults, A1C lined up with different resting brain rhythms

GeroScience published a magnetoencephalography study online on 9 November 2026. Maggie P. Rempe, Molly E. Voller, and colleagues compared 37 biomarker-positive people on the Alzheimer spectrum with 43 cognitively normal aging adults. Everyone had a resting-state scan, an A1C blood test as the glycemic measure, and a neuropsychological battery. A1C and group interacted in the delta and alpha bands (p < 0.001). In the Alzheimer group, higher A1C lined up with lower delta power across a wide stretch of frontotemporal and inferior parietal cortex. In the comparison group, higher A1C lined up with lower alpha power across inferior frontal and temporal cortex. Delta activity in superior frontal cortex carried the A1C association with attention scores in the Alzheimer group. The abstract does not give age or sex. This is one resting-state recording. It is not a glycemic rule. DOI 10.1007/s11357-026-02641-w. Not medical advice.

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Neurology · 9 Nov 2026 · Aging

In 4,822 Korean adults, a lower gait score lined up with later dementia at age 65, and the link faded by the mid-80s

Neurology published a prospective cohort on 9 November 2026. Youjung Choi, Jiyoung Jeong, and colleagues used the Korean Longitudinal Study on Cognitive Aging and Dementia. Of 6,818 eligible people, 4,822 were analyzed. Mean age was 69.6 years (standard deviation 6.3). 2,719 (56.4 percent) were women. Median follow-up was 6.2 years (interquartile range 3.8 to 8.1). 251 developed dementia and 458 died. Gait was scored with the Performance-Oriented Mobility Assessment. The gait-dementia curve was nonlinear (p = 0.002), rising as scores left the ceiling and peaking near 9 to 10, where the estimates got imprecise. Age changed the association (interaction p < 0.001). A gait score of 11 versus 12 had a hazard ratio of 3.13 (95 percent CI 1.82 to 5.37) at age 65, 1.36 (0.98 to 1.87) at age 75, and 0.59 (0.37 to 0.94) at age 85. The curves crossed at an estimated 78.6 years. Balance did not show the same age pattern. The cohort was ethnically narrow. DOI 10.1212/WNL.0000000000218711. Not medical advice.

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Neurology · 9 Nov 2026 · Research

In 816 people after stroke thrombectomy, intensive blood-pressure lowering lined up with worse 90-day scores in men, and not in women

Neurology published an exploratory secondary analysis on 9 November 2026. Renjun Gu, Xuan Zhu, and colleagues reanalyzed ENCHANTED2/MT, an open-label trial with blinded end-point review at 44 hospitals in China. Adults had a large-vessel stroke, successful reperfusion, and systolic blood pressure that stayed high within 3 hours. The sample was 816 people, mean age 67.6 years (standard deviation 12.0), 38 percent women. In men, intensive lowering was tied to a worse 90-day modified Rankin scale (adjusted common odds ratio 1.91; 95 percent CI 1.29 to 2.83). In women the estimate was 0.94 (0.56 to 1.57). The ratio of those odds ratios was 0.49 (0.26 to 0.94). Each 5 mm Hg higher mean systolic pressure was tied to a worse score in men (adjusted common odds ratio 1.11; 95 percent CI 1.03 to 1.20) and not in women (0.95; 0.85 to 1.05; ratio 0.85; 0.75 to 0.97). Variability in systolic pressure showed a weaker sex split. The authors say this should be tested on purpose before anyone uses it to set a different target for women and men. NCT04140110. DOI 10.1212/WNL.0000000000218703. Not medical advice.

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