ScienceDaily · 29 Oct 2026 · Exercise
ScienceDaily posted this release on 29 October 2026. The trial is RESET for Remission, published in The Lancet Regional Health - Americas and presented at the European Association for the Study of Diabetes meeting in Milan. Kaberi Dasgupta (McGill) and Tom Yates (Leicester) led an open-label randomized trial at three centers (Leicester, McGill, and Alberta). Adults aged 18 to 45 with early-onset type 2 diabetes and obesity, and not using insulin, were eligible. From 24 September 2021 to 6 June 2025 the teams randomized 96 people (40 in the UK and 56 in Canada): 50 to the intervention (24 women and 26 men) and 46 to usual care (21 women and 25 men). Mean age was 38 and mean BMI was 35.2. Eighty-six of 96 people (90 percent) finished. Remission at 24 weeks meant an HbA1c under 6.5 percent and no glucose-lowering medicines for at least 12 weeks. Missing remission data counted as no remission. That bar was met by 27 of 50 people (54 percent) versus 2 of 46 (4 percent). MedPage Today reported an adjusted odds ratio of 21.6 (95 percent CI 6.2 to 114.5). ScienceDaily rounded the same contrast to about 21 times. Among people with weight data, 47 in the intervention went from 100.7 kg to 92.3 kg (down 8.4 kg) and 43 in usual care went from 103.2 kg to 102.0 kg (down 1.2 kg). The adjusted extra loss was 7.5 kg, including 6.6 kg extra fat. For weeks 1 to 12 the plan was 800 to 900 kcal a day (30 percent protein, 50 percent carbohydrate, 20 percent fat), using Optifast and then Optifast in the UK or ProtiDiet in Canada, plus twice-weekly supervised aerobic and resistance work and one independent session. Weeks 13 to 24 used a weight-maintenance eating plan and independent sessions. Glucose-lowering and blood-pressure medicines were stopped only under the study clinicians, and the blood-pressure stop required no albuminuria. No severe adverse events were reported. Other events occurred in 43 of 50 versus 6 of 46, mostly early, including constipation, headache, dizziness, and fatigue. MedPage also described hypertension remission in 56 percent versus 27 percent. That figure is from MedPage's account of the same trial. This was a six-month research program. It is not a do-it-yourself plan, and it is not a reason to stop medicines outside a clinician's care. Not medical advice.
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- Under 40
- 40–59
- Metabolic / glucose
- Exercise
- Nutrition
- Cardiovascular / lipids
