Human study · Exercise · 20 Oct 2026
Impact of habitual physical activity and age on T cell metabolism and activation via β2-adrenergic receptor modulation
Source: Frontiers in Aging
What the research found
BackgroundAgeing impairs T cell function and responses to vaccines and infections. Effective T cell function requires rapid metabolic switching towards glycolysis, which becomes dysregulated with age. We have shown that physically active older adults have T cells that are more functional and metabolically fit. As exercise acutely elevates adrenaline and mobilises T cells via β2-adrenergic receptors (β2-AR), we hypoth
Evidence level: Human study. A study in people, but an association isn't proof of cause.
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