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EurekAlert · 30 Mar 2026 · Supplements / medicine

Six-hour eating window and calorie counting both lowered testosterone in women with PCOS

Study (randomized trial). Krista Varady and University of Illinois Chicago colleagues report in Nature Medicine on 76 pre-menopausal women with PCOS. Six months of time-restricted eating (1–7 p.m.) versus calorie counting each cut intake by about 200 kcal/day and weight by about 10 lb. Both lowered testosterone; only TRE reduced free androgen index (active testosterone reaching tissues) without harming other female hormones in this report. PCOS is a clinical diagnosis; this is not a fertility protocol or a substitute for clinician-guided care. Educational nutrition notes, not medical advice.

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  • study women
  • nutrition
  • study

University of Jyväskylä · 24 Mar 2026 · Exercise

Self-selected music stretched cycling time-to-exhaustion by about six minutes in 29 adults

Study (crossover). Danso, Ihalainen and colleagues had 29 recreationally active adults cycle to exhaustion at ~80% peak power with self-selected 120–140 bpm music versus no music. Time-to-exhaustion was longer with music (35.6 vs 29.8 min). End-exercise heart rate, VO2, RPE, and lactate were similar; VO2peak did not moderate the effect. Small lab trial. Educational exercise notes, not a playlist protocol.

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  • 40–59
  • study
  • fitness

EurekAlert · 9 Mar 2026 · Exercise

Eight weeks of HIIT expanded mitochondrial cristae in men aged 40–65, including those with type 2 diabetes

Study (training trial). Martin Eisemann de Almeida and colleagues at the University of Southern Denmark and Steno Diabetes Center Odense analysed muscle biopsies from 44 men aged 40–65 (15 with overweight and type 2 diabetes, 15 with overweight without diabetes, 18 of normal weight) after eight weeks of HIIT (rowing or cycling intervals, three sessions/week). Electron microscopy of about 11,000 mitochondria showed more mitochondria and about 7% expansion of cristae (the inner membrane where energy is produced) across groups, including men with type 2 diabetes. Small, men-only sample; maintenance after stopping training was not tested. This is not a diabetes treatment protocol. Educational exercise notes, not medical advice.

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  • study
  • fitness
  • men

EurekAlert · 9 Mar 2026 · Supplements / medicine

Two years of a daily multivitamin slowed five epigenetic clocks by about four months

Study (RCT analysis). Mass General Brigham investigators report from COSMOS that older adults taking a daily multivitamin for two years showed slower aging across five DNA-methylation clocks versus placebo, including significant slowing on two clocks that predict mortality — about four months less biological aging over two years, with larger effects in people who started biologically older than their years. Clock change is not proof of fewer diseases or longer life. Educational supplement notes, not a reason to start or stop prescribed medicine, and not a disease treatment claim.

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  • study aging
  • aging
  • study

JAMA Neurology / PMC · 2 Mar 2026 · Supplements / medicine

Low-dose lithium missed coprimary endpoints in a two-year mild cognitive impairment pilot

Study (pilot RCT). Ariel Gildengers and University of Pittsburgh investigators report LATTICE in JAMA Neurology (doi 10.1001/jamaneurol.2026.0072): 80 adults aged 60+ with MCI (56% female; mean ages ~72–73) randomised to low-dose lithium carbonate or placebo for two years. None of six coprimary outcomes met the prespecified p<0.01 threshold (verbal memory, visuospatial memory, PACC composite, hippocampal volume, cortical gray matter, plasma BDNF). CVLT-II delayed recall declined 1.42 points/year on placebo vs 0.73 on lithium (difference 0.69; 95% CI 0.01–1.37; p=0.05), a nominal signal that did not survive multiple-comparison control. Lithium is a prescription medicine. This is not a reason to start, stop, or replace any prescribed drug, and lithium is not a dietary supplement SKU. Off-label cognitive use is clinician-only. Educational trial notes, not medical advice.

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  • study
  • cognition
  • nutrition
  • off-label-context

VitaLonga is an educational longevity resource, not a pharmacy, clinic, or doctor. Content is not medical advice and is not intended to diagnose, treat, cure, or prevent any disease (DSHEA). Supplements can interact with medications and are not appropriate in every pregnancy or health condition. Consult a licensed clinician, especially if you take medications, are pregnant or nursing, or have a diagnosed condition.