PsyPost / JAMA Network Open · 7 Sept 2026 · Aging
Study (observational). M. Pia Campagna, Riley M. Bove, and colleagues report in JAMA Network Open (doi 10.1001/jamanetworkopen.2026.30973; PsyPost 7 September 2026) on 2,603 older women in the Religious Orders Study and the Rush Memory and Aging Project. Average age at enrollment was 78, with no known dementia then, and follow-up ran as long as 18 years with yearly cognitive testing. Reproductive history was recalled, including age at menopause and whether it was natural or surgical. Brain autopsy was available for 1,287 women, and 774 had MRI about every two years. Earlier menopause lined up with faster decline in global cognition and episodic memory, and with an Alzheimer diagnosis at a younger age. Models estimated that menopause ten years earlier corresponded to nearly two fewer years free of Alzheimer disease. Cognitive decline and earlier diagnosis were stronger after surgical menopause. On scans, earlier natural menopause lined up with faster accumulation of white-matter hyperintensities: about 15 percent more of that injury over ten years for menopause five years earlier. That white-matter pattern was not seen in the surgical group. The link with total brain-volume loss was small. A shorter reproductive span lined up with the same cognitive direction. This cannot prove early menopause causes later dementia. Hormone therapy was not tested here; Bove noted that higher-quality trials have not shown it protects the brain, and follow-up in those trials may still be short. Recall of period dates can be imperfect, and pregnancies, breastfeeding, and contraceptive use were not fully captured. This is a different study from the September menopause proteomic score. Educational aging notes. Not a reason to start, stop, or time a hormone treatment.
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- Women
- 60+
- Cognitive / dementia research
