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Frontiers in Aging · Added 25 Sept 2026 · Supplements / medicine

CaroRite™ for improving skin health and the visible signs of aging - a randomised, double-blind, placebo-controlled trial

BackgroundThere is an increasing need to identify novel ingredients that can be safely utilized to enhance skin function and mitigate skin aging. Carotenoid supplementation shows promise in improving skin health and reducing signs of aging, owing to its antioxidant and anti-inflammatory properties.AimThis randomised, double-blind, placebo-controlled study aimed to investigate the efficacy of a carotenoid supplement,

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  • clinical trial
  • aging
  • inflammation
  • study

Frontiers in Aging · Added 25 Sept 2026 · Exercise

Unraveling skeletal muscle senescence in an in vitro cell culture model

IntroductionSkeletal muscles are crucial for voluntary movement, posture, breathing, joint stability, and therefore are essential for maintaining overall health and quality of life. Aging, sarcopenia, cancer, immobilization, and several muscle pathologies can have an impact on muscle function, and muscle cell senescence is associated with these conditions.MethodsHere we aimed to develop a primary cell culture model t

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  • original research
  • muscle
  • aging

Frontiers in Aging · Added 25 Sept 2026 · Aging

Association of smoking cessation with late-life frailty risk: the Singapore Chinese health study

ObjectiveTo examine whether smoking cessation, in terms of duration and age at quitting, was associated with late-life physical frailty.DesignProspective population-based cohort study.SettingChinese living in Singapore.ParticipantsWe analyzed data from 4,574 men (mean baseline age 52.7 years, range 45–65 years) enrolled in the Singapore Chinese Health Study.MeasurementsParticipants self-reported smoking behaviors at

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  • original research
  • study

Frontiers in Aging · Added 25 Sept 2026 · Aging

Role of essential and trace elements in chronic myeloid leukemia: associations with serum trace element profiles and hematological parameters

BackgroundChronic myeloid leukemia is a myeloproliferative malignancy characterized by the Philadelphia chromosome with uncontrolled expansion of myeloid cells. Trace elements are essential for cellular metabolism, DNA repair, antioxidant defence, and immune regulation, and their imbalance may influence leukemogenesis and contribute to oxidative stress, immune dysregulation, and hematological alterations. Profiling t

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  • original research

Frontiers in Aging · Added 25 Sept 2026 · Nutrition

Sex-specific effects of automated feeding on lifespan and reproduction in Nothobranchius furzeri

IntroductionNothobranchius furzeri, commonly known as African turquoise killifish, has emerged as a powerful model organism in diverse biological research areas owing to its exceptionally short lifespan of 4‐6 months. Dietary choices can significantly impact the physiology of this fish and its median longevity, prompting considerations on live versus dry food and feeding frequencies.MethodsHere, we present a novel, c

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  • original research
  • aging
  • longevity

Frontiers in Aging · Added 25 Sept 2026 · Aging

Explanatory limitations of CSF, plasma, and MRI biomarkers for inflammation and blood–brain barrier disruption in dementia

Inflammation and blood–brain barrier (BBB) disruption are increasingly implicated in cognitive decline, but it remains unclear which fluid and imaging measures best capture these processes. Participants were drawn from two overlapping research programs, MarkVCID and UNM ADRC. We studied 149 participants with Alzheimer’s disease, leukoaraiosis, mixed dementia, subcortical ischemic vascular dementia, or memory impairme

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  • Cognitive / dementia research
  • original research
  • cognition
  • inflammation

Frontiers in Aging · Added 25 Sept 2026 · Aging

Rumo zhentong Yin for blood-stasis-type osteoporotic pain: protocol of a randomized, single-blind, controlled trial

BackgroundOsteoporosis (OP) is a metabolic skeletal disease characterized by reduced bone mass and micro-architectural deterioration, with Osteoporotic pain (OPP) as its most common clinical symptom, which markedly impairs quality of life. Modern pharmacologic treatments’ limitations are obvious with population aging, so the cost-effective interventions for OPP are urgently needed. As an empirical formula, Rumo zhent

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  • original research
  • study

Frontiers in Aging · Added 25 Sept 2026 · Supplements / medicine

Narrative review of intravenous NAD+ and NAD+ precursors in wellness and translational medicine

BackgroundNicotinamide adenine dinucleotide (NAD+) is a major coenzyme critically involved in cellular metabolism, mitochondrial function, DNA repair, and stress-response signaling. Age-associated decline in NAD+ levels has generated interest in NAD+-augmenting strategies; however, recent large-scale human data indicate that whole-blood NAD+ concentrations do not decline with healthy aging per se. Despite increasing

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  • review
  • aging

Frontiers in Aging · Added 25 Sept 2026 · Aging

Structured lifestyle modification and biological aging: effects on PhenoAge, sclerostin, and GDF-15 in arab adults with prediabetes

BackgroundLifestyle modification programs (LMP) such as diabetes prevention programs may influence phenotypic aging trajectories, but evidence in Middle Eastern populations remains limited. This study examined the effects of a structured LMP on phenotypic age (PhenoAge) as the primary endpoint and circulating sclerostin (SOST) and growth differentiation factor-15 (GDF-15) as secondary endpoints in a cohort of Arab ad

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  • Metabolic / glucose
  • original research
  • study

Frontiers in Aging · Added 25 Sept 2026 · Aging

Molecular markers, mechanisms and metrics of biological aging: a scoping review

Biological aging is a rapidly growing area of research, which entails characterizing the rate of aging independent of an individual’s chronological age. In this scoping review, we analyze the results of biological aging research in 435 papers published in a 12 year window spanning 2011 through June 2023, 309 of which focus on non-methylation-based biomarkers, revealing changing patterns of molecular markers of biolog

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  • review

VitaLonga is an educational longevity resource, not a pharmacy, clinic, or doctor. Content is not medical advice and is not intended to diagnose, treat, cure, or prevent any disease (DSHEA). Supplements can interact with medications and are not appropriate in every pregnancy or health condition. Consult a licensed clinician, especially if you take medications, are pregnant or nursing, or have a diagnosed condition.