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University of Barcelona / ScienceDaily · 26 Sept 2026 · Supplements / medicine

In obese mice, tirzepatide switched on brown fat even when they ate the same amount as untreated mice

Study (animal). Marion Peyrou and colleagues at the University of Barcelona report in Biomedicine & Pharmacotherapy (doi 10.1016/j.biopha.2026.119057; ScienceDaily 26 September 2026, citing the university). Obese mice on a high-fat diet received tirzepatide and were compared with mice that did not get the agent but ate the same amount. With intake matched, tirzepatide still switched on brown adipose tissue, the fat that uses energy rather than mainly storing it. The authors link that to batokines and a greater capacity to burn metabolic energy. They say active brown fat uses glucose and fat and could help explain lower blood glucose, beyond the effect of eating less. Earlier attempts to switch on brown fat have stumbled on unwanted heart effects; the group says this agent did not show those effects in the mice. They warn that mouse and human fat, and responses to this agent, can differ, and they ask for human fat studies. Tirzepatide is a prescribed dual GIP and GLP-1 agent. A mouse result is not a reason to start, stop, or swap it. Educational notes. Not a substitute for clinician care. Educational supplement parallel (not a replacement): When headlines discuss GLP-1 medicines and aging, people often research food-first fiber or bitter-botanical “pathway support” formulas. Those are not semaglutide, not compounded GLP-1, and not a substitute for a prescribed GLP-1 drug. Mouse or marketing claims are hype until human outcome data exist. Weakly evidenced. Store: /store/glp1-pathway-support. Not medical advice. Not a substitute for a prescribed medicine. Off-label prescription use is clinician-only. VitaLonga does not diagnose, treat, or cure disease. Never start, stop, or replace a prescription with a supplement on the basis of a headline.

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  • Metabolic / glucose
  • Nutrition
  • Medicine
  • study
  • nutrition
  • glp1

Eli Lilly / EASD / EurekAlert · 26 Sept 2026 · Supplements / medicine

Oral orforglipron tracked up to 14% weight loss in women before, during, and after menopause

Study (post-hoc analysis of trials). Hunter Thomas Hoffman and colleagues at Eli Lilly, the sponsor and maker, present an EASD analysis (EurekAlert 26 September 2026). They split women in ATTAIN-1 (overweight or obesity without diabetes) and ATTAIN-2 (both conditions) into pre-menopause, peri-menopause, and post-menopause. Each stage had about 142 to 225 women on orforglipron or placebo. At 72 weeks, body weight fell by up to 14% in each menopausal stage in both trials, with waist drops of up to 12.5 cm. Up to 83% lost at least 5% of body weight, versus 30% on placebo. More women on orforglipron moved into a lower waist-to-height group. Every author works for the manufacturer. The release points to a results table in the full abstract for the stage-by-stage figures, so those finer numbers are not restated here. Orforglipron is a prescribed oral GLP-1 receptor agonist. This is not a suggestion to start, stop, or swap any treatment, and it is not a substitute for clinician care. Educational notes. Educational supplement parallel (not a replacement): When headlines discuss GLP-1 medicines and aging, people often research food-first fiber or bitter-botanical “pathway support” formulas. Those are not semaglutide, not compounded GLP-1, and not a substitute for a prescribed GLP-1 drug. Mouse or marketing claims are hype until human outcome data exist. Weakly evidenced. Store: /store/glp1-pathway-support. Not medical advice. Not a substitute for a prescribed medicine. Off-label prescription use is clinician-only. VitaLonga does not diagnose, treat, or cure disease. Never start, stop, or replace a prescription with a supplement on the basis of a headline.

Read at Eli Lilly / EASD / EurekAlert →Our summary♡ Save

  • Women
  • Metabolic / glucose
  • Medicine
  • Aging
  • study
  • glp1

Frontiers in Aging · Added 25 Sept 2026 · Supplements / medicine

Narrative review of intravenous NAD+ and NAD+ precursors in wellness and translational medicine

BackgroundNicotinamide adenine dinucleotide (NAD+) is a major coenzyme critically involved in cellular metabolism, mitochondrial function, DNA repair, and stress-response signaling. Age-associated decline in NAD+ levels has generated interest in NAD+-augmenting strategies; however, recent large-scale human data indicate that whole-blood NAD+ concentrations do not decline with healthy aging per se. Despite increasing

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  • Metabolic / glucose
  • Supplements
  • Medicine
  • Aging
  • review
  • aging

Frontiers in Aging · Added 25 Sept 2026 · Supplements / medicine

CaroRite™ for improving skin health and the visible signs of aging - a randomised, double-blind, placebo-controlled trial

BackgroundThere is an increasing need to identify novel ingredients that can be safely utilized to enhance skin function and mitigate skin aging. Carotenoid supplementation shows promise in improving skin health and reducing signs of aging, owing to its antioxidant and anti-inflammatory properties.AimThis randomised, double-blind, placebo-controlled study aimed to investigate the efficacy of a carotenoid supplement,

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  • Supplements
  • Aging
  • clinical trial
  • aging
  • inflammation
  • study

ScienceDaily · 24 Sept 2026 · Supplements / medicine

Scientists thought they knew how this 70-year-old leukemia drug worked

A 70-year-old leukemia drug is still revealing new secrets. Researchers found that removing a protein called NUDT5 protected cells from the drug, even though simply blocking the protein had little effect. The unexpected result points to a hidden cellular role that could help explain why people respond differently to certain leukemia treatments.

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  • Cancer
  • Medicine
  • news

ScienceDaily · 24 Sept 2026 · Supplements / medicine

GLP-1 weight loss and diabetes drugs linked to nutritional deficiencies in nearly 1 in 6 children

Children taking GLP-1 medications (such as Victoza, Saxenda, Trulicity, and Ozempic) for weight loss, prediabetes, or type 2 diabetes may face an overlooked risk: nutritional deficiencies. A new study found that nearly 1 in 6 young patients developed a diagnosed deficiency within a year of starting treatment, with vitamin D deficiency affecting about 12%. Educational supplement parallel (not a replacement): When headlines discuss GLP-1 medicines and aging, people often research food-first fiber or bitter-botanical “pathway support” formulas. Those are not semaglutide, not compounded GLP-1, and not a substitute for a prescribed GLP-1 drug. Mouse or marketing claims are hype until human outcome data exist. Weakly evidenced. Store: /store/glp1-pathway-support. Not medical advice. Not a substitute for a prescribed medicine. Off-label prescription use is clinician-only. VitaLonga does not diagnose, treat, or cure disease. Never start, stop, or replace a prescription with a supplement on the basis of a headline.

Read at ScienceDaily →Our summary♡ Save

  • Metabolic / glucose
  • Nutrition
  • Supplements
  • Medicine
  • Aging
  • nutrition
  • glp1
  • off-label-context
  • aging
  • study

News-Medical / Scientific Reports · 24 Sept 2026 · Supplements / medicine

Beetroot juice did not make trained swimmers faster in a pooled review

Study (systematic review and meta-analysis). Vega-Monzo, Ranchal-Sanchez, Jurado-Castro, and colleagues report in Scientific Reports (doi 10.1038/s41598-026-65495-4; News-Medical 24 September 2026). Searches of Web of Science, PubMed, and Scopus through 11 June 2026 found 12 eligible trials; nine, with 120 swimmers, could be pooled. Designs were mostly randomized crossovers of beetroot juice or nitrate against placebo. The included athletes were mostly young adult or university-level swimmers of both sexes, from moderately trained to elite, so this does not describe older swimmers. Most tests were 50 to 100 metres, with some repeated sprints; one trial used a 168 metre backstroke. Time-trial performance did not differ from placebo overall, and subgroups for sprints of 30 seconds or less, 30 to 90 seconds, and efforts longer than 90 seconds also showed no clear effect. Post-exercise lactate, from six studies and 69 swimmers, was similar. Perceived exertion, from seven studies and 100 swimmers, was slightly lower, but the studies disagreed and the easier feeling did not show up as faster swimming. Three trials were low risk of bias, six had some concerns, and three were high risk. GRADE certainty for performance was low because of bias and imprecision. The authors say current evidence does not support beetroot juice as a general performance aid for competitive swimming under the protocols studied, and a small effect cannot be ruled out. Educational supplement notes. Not a recommendation to take nitrate products.

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  • Women
  • Men
  • Under 40
  • Exercise
  • Supplements
  • study
  • fitness

EurekAlert / University of Southern California · 24 Sept 2026 · Supplements / medicine

More older Americans take five or more drugs, and about 1 in 5 still face a major interaction

Study (repeated cross-section). Dima Qato and colleagues report in JAMA (24 September 2026; doi 10.1001/jama.2026.17268) on nearly 5,000 community-dwelling US adults ages 62 to 85, comparing 2015–2016 with 2021–2023. Use of any prescription medication stayed about 84%, and any dietary supplement about 66%. Polypharmacy, five or more prescription medications at once, rose from 31% to 35.7%. Dietary-supplement polypharmacy rose from 12.6% to 16.7%. Regimens with a potentially major drug interaction fell from 25.7% to 22.3%, so more than 1 in 5 people were still in that group. Antidepressants, statins, and antiplatelet therapies were the classes most often involved. This is a surveillance snapshot, not advice to start or stop a medication or a supplement. Changes belong with a clinician. Educational notes.

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  • 60+
  • Cardiovascular / lipids
  • Nutrition
  • Supplements
  • Medicine
  • study
  • nutrition
  • off-label-context

UCLA Health · 23 Sept 2026 · Supplements / medicine

A 12-month estriol-plus-progesterone case series tracked less menopause brain fog in 20 women

Study (observational case series, not a randomized trial). Rhonda Voskuhl and colleagues report in Scientific Reports that 20 menopausal women, average age 53, described less brain fog and better concentration, working memory, processing speed, verbal memory, and problem-solving after 12 months on a customized estriol-plus-progesterone regimen, compared with their own baseline. There was no placebo group. In midlife female mice, estriol lowered hippocampal pathology markers and improved working and spatial memory. Estriol is a prescription hormone, not a supplement, and no treatment is FDA-approved specifically for menopause cognitive symptoms. The regimen was invented by the senior author; UCLA licenses it to CleopatraRX (sold as PearlPAK), and Voskuhl is a medical advisor to that company. Clinician-only. Not medical advice and not a substitute for prescribed care.

Read at UCLA Health →Our summary♡ Save

  • Women
  • 40–59
  • Cognitive / dementia research
  • Supplements
  • Medicine
  • Aging
  • study
  • cognition
  • off-label-context

VitaLonga is an educational longevity resource, not a pharmacy, clinic, or doctor. Content is not medical advice and is not intended to diagnose, treat, cure, or prevent any disease (DSHEA). Supplements can interact with medications and are not appropriate in every pregnancy or health condition. Consult a licensed clinician, especially if you take medications, are pregnant or nursing, or have a diagnosed condition.