Clinical trial · Supplements / medicine · 23 Sept 2026
A 12-month estriol-plus-progesterone case series tracked less menopause brain fog in 20 women
Source: UCLA Health
What the research found
Study (observational case series, not a randomized trial). Rhonda Voskuhl and colleagues report in Scientific Reports that 20 menopausal women, average age 53, described less brain fog and better concentration, working memory, processing speed, verbal memory, and problem-solving after 12 months on a customized estriol-plus-progesterone regimen, compared with their own baseline. There was no placebo group. In midlife female mice, estriol lowered hippocampal pathology markers and improved working and spatial memory. Estriol is a prescription hormone, not a supplement, and no treatment is FDA-approved specifically for menopause cognitive symptoms. The regimen was invented by the senior author; UCLA licenses it to CleopatraRX (sold as PearlPAK), and Voskuhl is a medical advisor to that company. Clinician-only. Not medical advice and not a substitute for prescribed care.
Evidence level: Clinical trial. This is among the stronger kinds of evidence, but one study rarely settles a question.
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