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Frontiers in Aging · 2 Oct 2026 · Aging

Opportunities to enhance assisted living facility care quality through interprofessional collaborative practice

Interprofessional Education (IPE) is increasingly recognized as a vital strategy for enhancing the quality of care in assisted living facility (ALF) settings. By fostering collaboration among healthcare professionals such as nurses, nurses’ aides, social workers, physicians, and administrators, IPE promotes a shared and more robust understanding of resident needs and care goals. This opinion article argues that great

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  • Aging
  • perspective

Frontiers in Aging · 30 Sept 2026 · Aging

Comprehensive profiling of phenotypic features of memory T- and B-cells from birth to the onset of old age

IntroductionHuman aging is accompanied by profound and continuous remodeling of the immune system, characterized by rhythmic, stage-specific patterns. These features are characterized by waves of cellular differentiation, network reorganization, and functional recalibration, a phenomenon encompassed by the concept of immunobiography.MethodsThis study focuses on T- and B-cell memory immunophenotypes that shape adaptiv

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  • Cognitive / dementia research
  • Aging
  • original research
  • cognition
  • study

Frontiers in Aging · 30 Sept 2026 · Aging

Synovial fluid-derived extracellular vesicles modulate joint cell function in osteoarthritis

IntroductionOsteoarthritis (OA) is an age-related joint disease characterized by chronic inflammation and extracellular matrix degradation. Extracellular vesicles (EVs) in synovial fluid (SF) may modulate intercellular communication and influence disease progression.Material and methodsSF, cartilage, and synovial tissue were collected from knee OA patients (n = 68). SF-derived EVs (SF-EVs) were isolated by size exclu

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  • Aging
  • original research
  • inflammation

Frontiers in Aging · 29 Sept 2026 · Aging

Immune system ontogeny—a subtle evolution to perfection

It is well known that both innate and adaptive immune systems in newborns are immature, making them highly susceptible to infection. Additionally, pre-term newborns with hindered immune systems are more prone to increased mortality and morbidity. Newborns are capable of mounting adaptive immune responses, but their capability to develop long-lasting immunity is limited. Thus, the fetus and newborn’s immune system is

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  • Aging
  • Longevity
  • review

Netherlands Institute for Neuroscience / Brain Communications · 26 Sept 2026 · Aging

Favorite music still stirred the brain in Alzheimer's disease, with a weaker movement-area response in frontotemporal dementia

Study (brain imaging). Jochum van 't Hooft, Wietske van der Zwaag, and colleagues at Alzheimer Center Amsterdam and the Netherlands Institute for Neuroscience report in Brain Communications (doi 10.1093/braincomms/fcag196; Medical Xpress 26 September 2026). People with Alzheimer's disease, people with frontotemporal dementia, and healthy participants listened to personally meaningful music and to neutral music while functional MRI recorded brain activity. The scanner paused briefly so the music could be heard between image acquisitions. Favorite music produced more brain activity than neutral music in all three groups. In frontotemporal dementia, activity was lower in the supplementary motor area, a region involved in movement and in aspects of musical processing and memory. The Alzheimer's response was closer to that of the healthy participants. The release does not give the number of volunteers or their ages. The authors say this is not proof that a particular music therapy will help, and that the response is weaker in some people than in others. What mattered was music that belonged to that person. Educational notes.

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  • Cognitive / dementia research
  • study
  • cognition

Frontiers in Aging · Added 25 Sept 2026 · Aging

Peripheral adaptive immune remodeling associated with severe hearing loss in older adults: a single-center flow-cytometry study with mouse cochlear transcriptomic context

ObjectiveTo investigate the association between severe hearing loss and systemic immune aging in older adults using participant-level clinical immunophenotyping, and to explore potential inflammatory pathways and cellular contexts using public mouse cochlear transcriptomic data.MethodsWe analyzed a single-center cohort of 76 older adults, classified into normal hearing (NH), mild-to-moderate hearing loss (MMHL), or s

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  • 60+
  • Aging
  • original research
  • inflammation
  • study

Frontiers in Aging · Added 25 Sept 2026 · Aging

The association between digital literacy and cognitive function in older adults: the multiple mediating roles of self-efficacy, social participation, and psychological resilience

BackgroundDigital literacy refers to the ability to safely and effectively use digital technologies to access, manage, and apply information for daily living and social participation, and has been recognized as a key strategy for promoting healthy aging. However, limited research has simultaneously examined multiple psychosocial mechanisms underlying the relationship between digital literacy and cognitive function in

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  • 60+
  • Cognitive / dementia research
  • Aging
  • original research
  • cognition

Frontiers in Aging · Added 25 Sept 2026 · Aging

Cognitive and behavioral benefits of newspaper reading in community-dwelling older adults: a feasibility randomized controlled trial

IntroductionThere are reports suggesting that reading newspapers is an accessible daily intellectual activity that may help prevent neurocognitive disorders, while no prospective studies have accurately investigated its effectiveness on cognitive function.MethodsThis study is a randomized controlled trial designed to explore the effects of reading newspapers on cognitive function and activity levels in community-dwel

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  • 60+
  • Cognitive / dementia research
  • Aging
  • original research
  • cognition
  • study

Frontiers in Aging · Added 25 Sept 2026 · Aging

Association between preoperative cognitive impairment and perioperative neurocognitive disorders within 30 days after surgery in elderly patients: a secondary exploratory retrospective analysis

BackgroundPreoperative cognitive impairment (PCI) is a recognized risk factor for postoperative cognitive dysfunction, but its association with the broader syndrome of perioperative neurocognitive disorders (PND) within 30 days after surgery requires further investigation. This study aimed to evaluate the association between preoperative cognitive performance, assessed by the Montreal Cognitive Assessment (MoCA), and

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  • 60+
  • Cognitive / dementia research
  • Medicine
  • Aging
  • original research
  • cognition
  • study

Frontiers in Aging · Added 25 Sept 2026 · Aging

Gender differences in the association between marriage and epigenetic age

IntroductionBeing married is related to better health, but many studies reveal greater health benefits among men relative to women. Some research has indicated that married individuals exhibit decelerated epigenetic age relative to individuals who are not married, but questions remain regarding gender differences therein. The purpose was to investigate gender differences in associations of marital status to epigeneti

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  • Aging
  • original research

Frontiers in Aging · Added 25 Sept 2026 · Aging

Molecular markers, mechanisms and metrics of biological aging: a scoping review

Biological aging is a rapidly growing area of research, which entails characterizing the rate of aging independent of an individual’s chronological age. In this scoping review, we analyze the results of biological aging research in 435 papers published in a 12 year window spanning 2011 through June 2023, 309 of which focus on non-methylation-based biomarkers, revealing changing patterns of molecular markers of biolog

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  • Aging
  • review

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