Animal study · Nutrition · 14 Oct 2026
In aged mice, raising the RNA-processing gene SRSF1 in the liver extended median lifespan by 14 percent
Source: Nature Aging
What the research found
Study (cells and mice). A Wyss Institute team led by George Church and Alex Plesa, with Sascha Jung and Antonio del Sol, report in Nature Aging on 14 Oct 2026. A gene-expression age score trained on 464 human skin-fibroblast samples ranked the RNA-processing gene SRSF1 at the top of an overexpression screen. In old fibroblast lines, SRSF1 shifted senescence, protein-stress, and inflammatory signals toward a younger pattern and kept the cells as fibroblasts rather than turning on Yamanaka-style pluripotency. In aged mice, a liver-directed virus carrying SRSF1 slowed frailty and extended median lifespan by 14 percent compared with controls. The release does not state the sex of the mice. This is not a human treatment. Not medical advice.
Evidence level: Animal study. Results in animals or cells often don't carry over to people.
More nutrition news
- Eight weeks of a daily avocado and a cup of mango lined up with better blood-vessel function in 82 adults with prediabetes
- Eight months of medically tailored meals lined up with lower blood pressure and HbA1c in 110 adults with type 2 diabetes and high blood pressure
- A clinical nutrition report says potassium intake belongs beside sodium reduction for blood pressure
- In 22 elite women who play Australian rules football, in-season protein intake and fat intake were lower than in pre-season
- A diet higher in ultra-processed food tracked more depressive symptoms in older adults