Human study · Aging · Added 25 Sept 2026
Explanatory limitations of CSF, plasma, and MRI biomarkers for inflammation and blood–brain barrier disruption in dementia
Source: Frontiers in Aging
What the research found
Inflammation and blood–brain barrier (BBB) disruption are increasingly implicated in cognitive decline, but it remains unclear which fluid and imaging measures best capture these processes. Participants were drawn from two overlapping research programs, MarkVCID and UNM ADRC. We studied 149 participants with Alzheimer’s disease, leukoaraiosis, mixed dementia, subcortical ischemic vascular dementia, or memory impairme
Evidence level: Human study. A study in people, but an association isn't proof of cause.
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