Aging · 21 Sept 2026
A review argues chronically overactive DNA-damage “guardians” may drive aging even when tumor-suppressor genes are intact
Source: EurekAlert
What the research found
Commentary (review). An Aging (Albany NY) review (31 August 2026; press 21 September) terms the “guardian paradox”: tumor-suppressor DNA-damage responses that protect youth may, if chronically on (p53, p21, p16INK4a), push senescence and aging without new driver mutations. Framework, not a human intervention. Educational aging notes, not a senolytic pitch.
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