Nutrition · 14 Sept 2026
A Longo review maps how fasting remakes the epigenome — Sinclair flagged it as “ITOA”
Source: ScienceDirect
What the research found
Commentary (review). Valter Longo and colleagues, in Mechanisms of Ageing and Development, synthesize how fasting activates AMPK and sirtuins, shifting histone marks, DNA methylation, and non-coding RNAs toward autophagy and cellular maintenance. David Sinclair posted the paper on 14 September 2026 (“Fasting meets ITOA”). Review of animal and cell work, not a human outcome trial. Educational aging notes, not a fast-for-lifespan protocol. Sinclair-adjacent; farmed from the underlying review.
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