Clinical trial · Nutrition · 11 Nov 2026
In 30 women aged 40 or older, 8 weeks of food-based resistant starch did not change metabolic syndrome measures
Source: Food & Function
What the research found
An 8-week double-blind randomized pilot was published on 11 November 2026. The trial was in women. Thirty women aged 40 or older with at least two metabolic syndrome features were assigned 1:1 to higher-resistant-starch foods or control foods. Mean total dietary resistant starch was 7.9 grams a day versus 2.4 grams a day. The enrollment floor is 40, with no upper age in the abstract, so the age tags are 40 to 59 and 60 or older. Primary outcomes were the metabolic syndrome components and gut microbiome composition. Systolic blood pressure differed by an adjusted -1.7 mm Hg (95 percent CI -6.4 to 2.9, p=0.456). No primary metabolic outcome, and no global gut microbiome diversity or composition measure, differed between groups after multiplicity correction. An exploratory genus signal for Veillonella (adjusted difference 3.24, 95 percent CI 1.48 to 5.00, p<0.001) did not survive false-discovery correction (q=0.070). A glucose interaction also faded after one high-leverage point was removed. Registry KCT0011082. DOI 10.1039/d5fo05525c. Not medical advice.
Evidence level: Clinical trial. This is among the stronger kinds of evidence, but one study rarely settles a question.
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