Human study · Aging · 9 Nov 2026
In 37 people on the Alzheimer spectrum and 43 cognitively normal adults, A1C lined up with different resting brain rhythms
Source: GeroScience
What the research found
GeroScience published a magnetoencephalography study online on 9 November 2026. Maggie P. Rempe, Molly E. Voller, and colleagues compared 37 biomarker-positive people on the Alzheimer spectrum with 43 cognitively normal aging adults. Everyone had a resting-state scan, an A1C blood test as the glycemic measure, and a neuropsychological battery. A1C and group interacted in the delta and alpha bands (p < 0.001). In the Alzheimer group, higher A1C lined up with lower delta power across a wide stretch of frontotemporal and inferior parietal cortex. In the comparison group, higher A1C lined up with lower alpha power across inferior frontal and temporal cortex. Delta activity in superior frontal cortex carried the A1C association with attention scores in the Alzheimer group. The abstract does not give age or sex. This is one resting-state recording. It is not a glycemic rule. DOI 10.1007/s11357-026-02641-w. Not medical advice.
Evidence level: Human study. A study in people, but an association isn't proof of cause.
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