Human study · Aging · 12 Sept 2026
Scientists discover a hidden switch that shuts down inflammation
Source: ScienceDaily
What the research found
Study (human experimental). UCL’s Olivia Bracken, Derek Gilroy and colleagues report in Nature Communications that epoxy-oxylipins act as a brake on intermediate monocytes. Forty-eight healthy volunteers received a UV-killed E. coli forearm challenge; GSK2256294 (an sEH inhibitor) given before or after raised epoxy-oxylipins, sped pain relief, and cut intermediate monocytes without much change in redness or swelling. 12,13-EpOME appeared to suppress p38 MAPK. This is not a license to use sEH blockers for aging. Educational immune notes, not medical advice.
Evidence level: Human study. A study in people, but an association isn't proof of cause.
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