
UT Southwestern / Science Advances · 1 Oct 2026 · Research
In 9,879 ARIC participants, dozens of blood proteins sat on the path between social disadvantage and later heart failure
Study (observational proteomics). Amil Shah and colleagues, including UT Southwestern researchers Victoria Lamberson and Tammy Leonard, report in Science Advances (21 August 2026; 12(34):eaec5063; doi 10.1126/sciadv.aec5063; UT Southwestern roundup 1 October 2026). At ARIC visit 3 (1993–1995), 9,879 people free of heart failure (mean age 60, standard deviation 6; 46% men) had 4,955 plasma proteins measured. A social-disadvantage factor built from income, education, and area deprivation was linked to later heart failure through dozens of proteins: 36 in Black participants, 126 in white participants, and 12 shared. Eight proteins showed a mediation signal. Key results were checked in 49,396 UK Biobank participants. Mendelian randomization pointed to C1QTNF1 as a possible causal contributor; that is genetic evidence, not a treatment trial. Educational notes. This does not say a blood test should be ordered from a headline.
Read at UT Southwestern / Science Advances →Our summary♡ Save
- 40–59
- 60+
- Cardiovascular / lipids
- study










