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UC San Diego / Journal of the National Cancer Institute · 30 Sept 2026 · Exercise

In 253 breast cancer survivors, a year of remote walking coaching tracked better attention than wellness calls

Study (randomized trial). Sheri Hartman of UC San Diego Herbert Wertheim School of Public Health and colleagues report two papers from one trial in the Journal of the National Cancer Institute (30 September 2026). Two hundred fifty-three breast cancer survivors who had finished active care, reported low activity, and reported thinking difficulties were assigned to a remotely coached program aiming for 150 minutes a week of moderate-to-vigorous activity, or to a health-and-wellness program with the same call schedule and no activity coaching. The exercise arm added more weekly minutes (about 35 extra minutes a week versus the comparison arm). Primary outcomes — processing speed and self-rated thinking — did not differ between arms at 6 or 12 months; both arms improved. Secondary outcomes: attention was higher in the activity arm at 6 and 12 months; memory was higher at 6 months and not at 12 months. A random subset of 124 people gave blood. At the start, two epigenetic clocks put both arms about 8.7 years older than calendar age. Over 12 months those markers advanced about one month in the activity arm and about 10 months in the wellness arm. Faster epigenetic aging lined up with smaller attention gains. Larger trials are needed. Educational notes. This is not a cancer protocol.

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  • Women
  • 40–59
  • 60+
  • Cognitive / dementia research
  • Cancer
  • Exercise
  • Aging
  • study
  • fitness
  • cognition
  • aging

University of Copenhagen / Nature Aging · 29 Sept 2026 · Exercise

Lower cardiolipin in mouse muscle lined up with a fast-to-slow fiber shift; partial restoration reversed wasting in that model

Study (mice, plus human muscle samples that confirm a decline). Fabian Finger, Zach Gerhart-Hines, and colleagues at the University of Copenhagen report in Nature Aging (university news 29 September 2026) that cardiolipin, a fat almost exclusive to the inner mitochondrial membrane, falls in mouse and human muscle mitochondria with age and disease. Lowering cardiolipin in young mice reproduced the fast-to-slow fiber shift seen in aged mice and people. Restoring cardiolipin to about two-thirds of normal began to reverse wasting in that model and prevented the animals’ early deaths. Reactive oxygen species helped carry the signal: mopping them up with N-acetylcysteine blunted the fiber shift and, in these engineered mice, made wasting worse. Blocking the receptor ERRγ in cultured cells stopped the fiber switch. Human samples were used to confirm the cardiolipin drop, not to test a remedy. A cardiolipin-directed treatment has accelerated approval for Barth syndrome, a rare genetic condition, which is a different use. Educational notes. This is not advice to take an antioxidant pill.

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  • Exercise
  • Nutrition
  • Aging
  • study
  • aging
  • nutrition

City University of Hong Kong / EurekAlert · 26 Sept 2026 · Exercise

Around age 70, less ultra-processed food plus regular activity tracked a lower type 2 diabetes risk

Study (observational). Wenxin Xu and colleagues at City University of Hong Kong analysed 56,964 UK Biobank adults (mean age 69.5 years; 42.3% men) for an EASD presentation (EurekAlert 26 September 2026). Ultra-processed food was scored with the Nova system. Moderate-to-vigorous physical activity came from a week of wrist trackers. Over 7.8 years, 926 people developed type 2 diabetes. Each extra 10% of the diet by weight from ultra-processed food tracked a 7% higher risk. Meeting the World Health Organization mark of at least 150 minutes a week of that activity tracked a 39% lower risk than doing less. In the high genetic-risk group, a low ultra-processed share (about 11% or less by weight) tracked a 35% lower risk, and meeting the activity mark tracked a 33% lower risk. Together, the lower ultra-processed pattern plus that activity tracked a 49% lower risk in the high genetic-risk group, 70% in the intermediate group, and 59% in the low group. Among people whose diet was about 33% or more ultra-processed by weight, meeting the activity mark still tracked a 31%, 57%, and 58% lower risk across high, intermediate, and low genetic risk. This is an association, not proof that a kitchen change or a walking habit prevents diabetes. Educational notes.

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  • 60+
  • Metabolic / glucose
  • Exercise
  • Nutrition
  • study
  • fitness
  • nutrition

Frontiers in Aging · Added 25 Sept 2026 · Exercise

Effects of mind-body exercise on balance function in pre-frail and frail older adults: a systematic review and meta-analysis

BackgroundFrailty and pre-frailty are common geriatric conditions associated with reduced physiological reserve and a higher risk of falls. Mind–body exercises such as Tai Chi, Baduanjin, and Yoga are widely recommended as low-intensity interventions, while their specific effects on different aspects of balance remain unclear.ObjectiveThis systematic review and meta-analysis aimed to evaluate the effects of mind–body

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  • 60+
  • Exercise
  • Aging
  • systematic review
  • aging
  • fitness

Frontiers in Aging · Added 25 Sept 2026 · Exercise

Unraveling skeletal muscle senescence in an in vitro cell culture model

IntroductionSkeletal muscles are crucial for voluntary movement, posture, breathing, joint stability, and therefore are essential for maintaining overall health and quality of life. Aging, sarcopenia, cancer, immobilization, and several muscle pathologies can have an impact on muscle function, and muscle cell senescence is associated with these conditions.MethodsHere we aimed to develop a primary cell culture model t

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  • Cancer
  • Exercise
  • Aging
  • original research
  • muscle
  • aging

Journal of Cachexia, Sarcopenia and Muscle · 24 Sept 2026 · Exercise

Supervised exercise tracked better function and a shift in frailty markers near age 80

Study (human exercise intervention). Diego Marcos-Perez and colleagues report in the Journal of Cachexia, Sarcopenia and Muscle (doi 10.1002/jcsm.70362; 24 September 2026) on a multicentre comparison of a control group and a supervised exercise group in older adults, plus a separate testosterone-suppressed group of older men on androgen deprivation for prostate cancer. The control group had 24 people (14 women, 10 men; median age 80 plus or minus 5). The exercise group had 44 people (38 women, 6 men; median age 79 plus or minus 4). In the exercise group, Short Physical Performance Battery rose from 9.1 to 10.1, grip strength from 16.9 to 18.3 kg, and gait speed from 0.78 to 0.85 m/s. A sarcopenia score fell from 3.0 to 2.1, and Fried frailty criteria fell from 2.1 to 1.6 (all p at or below 0.004 within that before-after comparison). ANCOVA attributed better SPPB (p = 0.04) and grip strength (p < 0.005) to exercise versus control. Four of six FRAILOMIC markers (miR125b, miR194, RAGE, troponin) and six of seven BIOFRAIL markers (EGR1, CXCL8, GOS2, NSF, DDX11L1, miR454) reversed after training. Those marker shifts were not seen in 21 testosterone-suppressed men, who lost muscle. Latent class analysis called 36 people responders (32 from the exercise group) and 29 non-responders. miR454, EGR1, DDX11L1, and troponin best separated responders, and the BIOFRAIL trio miR454, EGR1, and DDX11L1 had an AUC of 0.83 for response. The public record does not state program length here. Mostly women, with men included. Association of a delivered program with function and blood or tissue markers, not a promise that any class reverses frailty. Educational exercise notes.

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  • Women
  • Men
  • 60+
  • Cancer
  • Exercise
  • Aging
  • study
  • fitness
  • aging

Frontiers in Aging · 24 Sept 2026 · Exercise

Ultrasonographic evaluation of quadriceps femoris muscle mass in critically ill patients aged 60 years and older: a prospective observational study

Background and aimsMuscle wasting is a common complication in critically ill older adults admitted to intensive care units (ICU), with significant implications for morbidity and mortality. Ultrasound represents a promising bedside tool for assessing muscle mass changes. This study aimed to evaluate changes in quadriceps femoris muscle mass using ultrasonography at ICU admission and after 7 days of stay in patients ag

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  • 60+
  • Exercise
  • Aging
  • Longevity
  • original research
  • muscle
  • aging
  • study

Adelaide University / News-Medical · 24 Sept 2026 · Exercise

Across 157 reviews, shorter and easier exercise programs eased pain more than longer ones

Study (umbrella review). Ben Singh, Carol Maher, and colleagues report in Pain Reports (6 July 2026; doi 10.1097/PR9.0000000000001455; Adelaide note 24 September 2026) on 157 systematic reviews, 2,736 randomized trials, and 221,279 participants. Exercise reduced pain versus control (pooled standardized mean difference −0.59; 95% CI −0.65 to −0.53). GRADE certainty was moderate. Benefits showed up for acute and chronic pain, including musculoskeletal, neurological, inflammatory, and cancer-related pain, and for aerobic work, resistance work, yoga, Pilates, and tai chi. Larger effects sat with lower intensity and programs shorter than 12 weeks, including programs under two hours a week. The Adelaide note put the average drop at about 1.1 points on a 0–10 scale, about 60% larger than the average relief reported for common pain tablets in separate chronic-pain trials. This is evidence about movement, not a reason to start or stop any prescribed care. Educational notes, not personal advice.

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  • Cancer
  • Exercise
  • study
  • fitness
  • inflammation

ACSM · 22 Sept 2026 · Exercise

Science Spotlight &#124; Late September 2026

ACSM’s From Around the Field Science Webinar Series Open to Students ACSM’s From Around the Field Science webinar series is designed to provide ACSM students and members with an opportunity to learn about the diverse science our members conduct. Join us for informal discussions with our ACSM members to hear more about what they study, [&#8230;] The post Science Spotlight | Late September 2026 appeared first on ACSM .

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  • Cognitive / dementia research
  • Exercise
  • member exclusive
  • science spotlight
  • parkinson's disease
  • physical activity
  • physical activity guidelines
  • physical education
  • study

ACSM · 22 Sept 2026 · Exercise

Hot Topic &#124; Energy Balance: A Key Component to Female Athlete Well-Being

Sports participation among women and girls has dramatically increased over the past decade, reflected in a record numbers of girls competing in high school and collegiate sports and women competing in the recent Olympic and Paralympic Games. For women and girls, sport participation is associated with opportunities to develop physical competence, improve components of fitness, [&#8230;] The post Hot Topic | Energy Bal

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  • Women
  • Exercise
  • hot topic
  • member exclusive
  • physical activity guidelines
  • sport/athletic performance
  • athlete development
  • atrophy
  • fitness

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