Human study · Supplements / medicine · 2 Sept 2026
Menopause may start changing the gut years before periods stop
Source: News-Medical
What the research found
Study (observational). Shieh, Karlamangla and colleagues, using 964 women in the SWAN Bone Cohort with a known final menstrual period (mean age about 49 at first visit), report in the Journal of Clinical Investigation that circulating markers of gut-barrier strain (FABP2 and sCD14) rose across about nine years around menopause. FABP2 began climbing about 2.5 years before the final period and slowed about 6.5 years after; sCD14 lagged by about six months. This is indirect blood-marker work, not a leaky-gut diagnosis or a probiotic trial. Educational menopause-aging notes, not medical advice.
Evidence level: Human study. A study in people, but an association isn't proof of cause.
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