Human study · Research · 28 Oct 2026
Three Nature papers map immune-cell genetics in nearly 2,000 people
Source: News-Medical
What the research found
News-Medical reported on 28 October 2026 three Nature papers from the Garvan Institute TenK10K project. The first phase sequenced nearly 2,000 Australians and measured gene activity in more than 5 million immune cells, linking variants to 16 diseases and 44 blood traits. One paper reports more than 180,000 effects on expression. Another links more than 69,000 tandem-repeat variants to expression. A third links more than 240,000 variants to how open the DNA is, and says that layer explained up to 23 percent more disease-linked regions than gene activity alone. One example is a variant that raises OSM in natural killer cells and tracks with higher irritable-bowel risk. Sex and age bands were not given. This is a map, not a personal genetic readout. Not medical advice.
Evidence level: Human study. A study in people, but an association isn't proof of cause.
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