Clinical trial · Supplements / medicine · 24 Oct 2026
Creatine with hard resistance sessions in perimenopausal women
Source: European Journal of Applied Physiology
What the research found
A 24 October 2026 paper in the European Journal of Applied Physiology randomized 51 perimenopausal women (mean age 46) to creatine, a placebo powder, or no training. The creatine and placebo groups did six weeks of twice-weekly high-intensity resistance training after a short loading phase. Creatine was linked with a small rise in prefrontal oxygenation during a memory test, higher sleep consistency at week 6 (about 7.4 points versus placebo), and fewer self-reported hot-temperature days. The authors call the analysis exploratory. Creatine is not hormone therapy and not a substitute for prescribed care. Not medical advice.
Evidence level: Clinical trial. This is among the stronger kinds of evidence, but one study rarely settles a question.
More supplements / medicine news
- In mice, the experimental drug KCL-286 reduced DNA breaks and brain inflammation in an Alzheimer's model
- In aged rats, two weeks of the experimental drug cinaciguat cut circulating amyloid-beta about in half and brought LDL down to youthful levels
- In 104 people with a sudden retinal-artery blockage, papaverine use lined up with better functional vision in a retrospective comparison
- A Cell Metabolism letter questions whether a fasting GLP-1 level shows how many gut L-cells a person has
- In FDA reports, caffeine and stimulant supplement use was tied to cardiac arrest about 11 times more often, and 45 percent of those cardiovascular reports were ages 18 to 34