Human study · Supplements / medicine · 13 Oct 2026
In more than 1 million women, 52 of 90 lab measures shifted abruptly around the final menstrual period
Source: Nature Medicine
What the research found
Study (observational records). Weizmann Institute researchers led by Uri Alon, with Glen Pridham and Yoav Hayut, report in Nature Medicine on 13 Oct 2026 that menopause is not only a slow drift. A method borrowed from astronomy corrected for different ages at the last period. Across more than 300 million laboratory tests from more than 1 million women in the US National Health and Nutrition Examination Survey and in Clalit records, 52 of 90 test types changed abruptly, including bone, liver, kidney, and cholesterol measures. Men of similar ages did not show that jump, and the shifts were smaller in women receiving menopausal hormone therapy. Sex-hormone changes sped up more than a decade before the final period. This is an association, not a reason to start or stop hormone therapy. Hormone decisions are clinician-only. Not medical advice.
Evidence level: Human study. A study in people, but an association isn't proof of cause.
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