Across 51 trials, eating patterns plus movement lowered epigenetic-age clocks; store-bought products did not

What the research found

Study (pooled intervention analysis). Raghav Sehgal and colleagues at Yale report in Nature Medicine (doi 10.1038/s41591-026-04562-9; healthmedicinet 29 September 2026) a re-analysis of 51 human intervention studies with more than 110 DNA-methylation biomarkers, including 16 major epigenetic clocks. They grouped the work into clinic-directed products, lifestyle programs, store-bought products, and procedures. Programs that combined a healthy eating pattern (Mediterranean, lower-carbohydrate, or lower-fat) with regular movement consistently lowered epigenetic-age estimates. Clinic-directed metabolic products, including metformin and semaglutide, and anti-TNF biologics that target an immune protein tied to inflammation, produced the largest average clock drops. Store-bought products and some procedures did not lower the clocks in this pool. Newer clocks moved more than older ones, and people who already had disease showed larger biomarker shifts than healthy volunteers. Clocks are not proof of longer life. Educational notes.

Evidence level: Animal study. Results in animals or cells often don't carry over to people.

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Read the original at Yale University / Nature Medicine