Animal study · Supplements / medicine · 5 Sept 2026
What can and can't slow down aging: New study offers clues
Source: Medical News Today
What the research found
Commentary covering a study. Yale researchers (Sehgal, Higgins-Chen and colleagues) pooled 51 human intervention studies in Nature Medicine and ran the same panel of 16 epigenetic clocks plus 94 other DNA-methylation markers. Diet patterns (Mediterranean, low-carb, or low-fat) plus regular exercise consistently lowered clock estimates. Prescription metformin, semaglutide, and anti-TNF therapies showed the largest average clock drops, often in people already treated for disease. Over-the-counter supplements were limited and inconsistent. Authors stress that a biomarker shift is not proof of extra healthy years. Metformin and GLP-1 drugs remain prescription medicines; off-label longevity use is clinician-only. This is not medical advice.
Evidence level: Animal study. Results in animals or cells often don't carry over to people.
Not medical advice. Not a substitute for a prescribed medicine. Off-label prescription use is clinician-only. VitaLonga does not diagnose, treat, or cure disease. Never start, stop, or replace a prescription with a supplement on the basis of a headline.
More supplements / medicine news
- In mice, the experimental drug KCL-286 reduced DNA breaks and brain inflammation in an Alzheimer's model
- In aged rats, two weeks of the experimental drug cinaciguat cut circulating amyloid-beta about in half and brought LDL down to youthful levels
- In 104 people with a sudden retinal-artery blockage, papaverine use lined up with better functional vision in a retrospective comparison
- A Cell Metabolism letter questions whether a fasting GLP-1 level shows how many gut L-cells a person has
- In FDA reports, caffeine and stimulant supplement use was tied to cardiac arrest about 11 times more often, and 45 percent of those cardiovascular reports were ages 18 to 34