Human study · Supplements / medicine · 15 Sept 2026
Frailty and heart health may share oxi-inflammaging and arterial-stiffness pathways
Source: News-Medical
What the research found
Commentary (narrative review). Mensah, Masoli, Rajkumar and colleagues write in the Journal of Human Hypertension (doi 10.1038/s41371-026-01214-w) that pre-frailty and frailty have been associated with about 70% higher overall cardiovascular disease risk and nearly three-fold higher cardiovascular death. They propose a “cardiovascular frailty” phenotype tying oxi-inflammaging, arterial stiffness, and blood-pressure dysregulation (hypertension, isolated systolic hypertension, orthostatic hypotension). Much biomarker evidence is cross-sectional. HYVET suggested frailty did not erase antihypertensive benefit after age 80, while other observational work has linked lower blood pressure to excess mortality in frail older adults. This is a conceptual review, not a trial of an exercise or drug protocol. Educational aging notes, not medical advice.
Evidence level: Human study. A study in people, but an association isn't proof of cause.
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