Human study · Research · 14 Nov 2026
In 9,156 adults aged 45 and older, a higher triglyceride-glucose index lined up with more chronic liver disease
Source: Annals of Nutrition and Metabolism
What the research found
A longitudinal cohort from the China Health and Retirement Longitudinal Study was published online on 14 November 2026. It included 9,156 adults aged 45 years and older. The abstract does not give a sex split. Over 7 years, 541 people (5.91 percent) developed chronic liver disease. Versus the lowest quartile, the highest triglyceride-glucose quartile had a hazard ratio of 1.42 (95 percent CI 1.10 to 1.83) after full adjustment. Related indices that folded in BMI or waist had hazard ratios of 1.62 (95 percent CI 1.25 to 2.09) and 1.40 (95 percent CI 1.09 to 1.81). The relationships were linear (all P for linearity <0.001). Adding the indices improved reclassification of risk. An association. DOI 10.1159/anm/abmag012. Not medical advice.
Evidence level: Human study. A study in people, but an association isn't proof of cause.
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