Human study · Supplements / medicine · 13 Nov 2026
In 38 healthy adults, a vitamin D3 bolus lined up with uneven next-day chromatin shifts
Source: Nutrients
What the research found
A one-day laboratory study was published on 13 November 2026. In the VitDPAS cohort, 38 healthy people received a body-weight-adjusted vitamin D3 bolus of 1000 IU per kg. The abstract does not give age or sex. Paired ATAC-seq and RNA-seq compared peripheral blood mononuclear cells on day 0 and day 1, about 24 hours after the bolus. Clusters were an accessibility increase (n=13), a mixed pattern (n=18), and an accessibility decrease (n=7). Within-group regions that differed at a false discovery rate under 0.05 numbered two, zero, and three. Filtering left 620 candidate regions. Differentially expressed genes numbered 74, 8, and 0. The link with baseline accessibility is descriptive, not predictive. A one-day observation after vitamin D3 supplementation. It is not a dosing guide. DOI 10.3390/nu18223777. Not medical advice.
Evidence level: Human study. A study in people, but an association isn't proof of cause.
More supplements / medicine news
- In normal-aging mice, acarbose lined up with better spatial memory, and the same pattern did not hold in an Alzheimer model
- In 23 adults with overweight or obesity, plant sterol supplementation raised a blood sterol and did not change LDL cholesterol
- In 3,142 older adults in Hong Kong, higher dietary magnesium lined up with better physical performance
- In 23,004 matched people with a prior skin cancer, oral nicotinamide lined up with fewer later eyelid cancers in the first year
- In 3,195 US adults, meeting activity and sitting guidelines lined up with about twice the odds of vitamin D sufficiency